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Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata
- Authors
- Han, X.H.; Hwang, J.H.; Hong, S.S.; Choe, S.; Lee, C.; Lee, M.S.; Lee, D.; Lee, M.K.; Lee, M.K.; Hwang, B.Y.
- Issue Date
- 2010
- Keywords
- Benzylated flavonoid; Cudrania tricuspidata; Monoamine oxidase inhibitor; Moraceae
- Citation
- Natural Product Sciences, v.16, no.2, pp.75 - 79
- Indexed
- SCOPUS
KCI
- Journal Title
- Natural Product Sciences
- Volume
- 16
- Number
- 2
- Start Page
- 75
- End Page
- 79
- ISSN
- 1226-3907
- Abstract
- Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 μM, respectively.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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