Relationship between obesity and n-terminal brain natriuretic peptide level as a prognostic value after acute myocardial infarction
- Authors
- Choi, S.G.; Jeong, M.H.; Ahn, Y.; Cho, J.G.; Kang, J.C.; Chae, S.C.; Hur, S.H.; Hong, T.J.; Kim, Y.J.; Seong, I.W.; Chae, J.K.; Rhew, J.Y.; Chae, I.H.; Cho, M.C.; Bae, J.H.; Rha, S.W.; Kim, C.J.; Choi, D.; Jang, Y.S.; Yoon, J.; Chung, W.S.; Seung, K.B.; Park, S.J.; Kim, J.H.; Choi, D.H.; Rhew, J.Y.; Kim, D.I.; Yoon, J.H.; Koo, B.K.; Kim, B.O.; Lee, M.Y.; Kim, K.S.; Hwang, J.Y.; Oh, S.K.; Lee, N.H.; Jeong, K.T.; Tahk, S.J.; Park, K.S.; Han, K.R.; Ahn, T.H.; Kim, M.H.; Yang, J.Y.; Rhim, C.Y.; Gwon, H.C.; Park, S.W.; Koh, Y.Y.; Joo, S.J.; Kim, S.J.; Jin, D.K.; Cho, J.M.; Kim, S.-W.; Kim, J.K.; Kim, T.I.; Nah, D.Y.; Park, S.H.; Lee, S.H.; Lee, S.U.; Chung, H.-J.; Cho, J.H.; Jin, S.W.
- Issue Date
- 2010
- Keywords
- Brain natriuretic peptide; Myocardial infarction; Obesity
- Citation
- Korean Circulation Journal, v.40, no.11, pp.558 - 564
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Circulation Journal
- Volume
- 40
- Number
- 11
- Start Page
- 558
- End Page
- 564
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/118334
- DOI
- 10.4070/kcj.2010.40.11.558
- ISSN
- 1738-5520
- Abstract
- Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n= 1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients. Copyright © 2010 The Korean Society of Cardiology.
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