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Regulating microenvironmental stimuli for stem cells and cancer cells using microsystems

Authors
Park, Joong YullTakayama, ShuichiLee, Sang-Hoon
Issue Date
2010
Publisher
OXFORD UNIV PRESS
Citation
INTEGRATIVE BIOLOGY, v.2, no.5-6, pp.229 - 240
Indexed
SCIE
SCOPUS
Journal Title
INTEGRATIVE BIOLOGY
Volume
2
Number
5-6
Start Page
229
End Page
240
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/118636
DOI
10.1039/c000442a
ISSN
1757-9694
Abstract
Cells express hundreds of different types of receptors, which they use to continuously monitor their chemical and mechanical microenvironments. Stem cells and cancer cells are particularly sensitive to microenvironmental cues because their interactions have profound effects on stem cell potency and tumorigenesis, respectively. Unlike conventional tissue culture in wells and dishes, microtechnology with dimensions on the cellular scale can be combined with materials, chemicals, physiological flows, and other effectors to provide high levels of control in a format more flexible than macroscale in vitro or in vivo systems, revealing stimulation-specific responses of stem cells and cancer cells. Microtechnology-integrated biology enable the simultaneous control of multiple numbers of biological microenvironmental factors in a high-throughput manner. In this review we present representative examples of the use of microtechnology systems to regulate the mechanical, chemical, topological, adhesive, and other environments of individual stem cells and cancer cells. We then explore the possibilities for simultaneous multimodal control of combinations of these environmental factors.
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