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Selection of a Patient Subgroup with Advanced Esophageal Squamous Carcinoma Who Could Benefit from Second-Line Chemotherapy

Authors
Kim, Seung TaePark, Kyong HwaOh, Sang CheulSeo, Jae HongShin, Sang WonKim, Jun SukKim, Yeul Hong
Issue Date
2010
Publisher
KARGER
Keywords
Chemotherapy, second line; Esophageal squamous cell carcinoma; Prognostic model
Citation
ONCOLOGY, v.79, no.5-6, pp.363 - 369
Indexed
SCIE
SCOPUS
Journal Title
ONCOLOGY
Volume
79
Number
5-6
Start Page
363
End Page
369
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/118689
DOI
10.1159/000322498
ISSN
0030-2414
Abstract
Despite first-line therapy, most patients with advanced esophageal squamous cell carcinoma (ESCC) experience disease progression and may become eligible for second-line chemotherapy. Although commonly used, the role of salvage chemotherapy in patients with recurrent or metastatic ESCC has not yet been established. We analyzed 53 patients who had received second-line chemotherapy after the failure of cisplatin-based combination chemotherapy with or without radiotherapy as first-line therapy in ESCC between March 2000 and June 2008. Median progression-free survival (PFS) and overall survival (OS) for second-line chemotherapy were 2.4 and 5.2 months, respectively, with an overall response rate of 18.9%. In multivariate analysis, Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 2 or more and PFS under first-line therapy <4 months were independent prognostic factors for decreased OS. OS was estimated based on the number of adverse prognostic factors: 0 = good; 1 = intermediate, and 2 = poor. The median OS for the good, intermediate, and poor prognostic groups were 11.2, 4.5 and 4.3 months, respectively (p < 0.001). The good prognostic group showed better OS than the intermediate or poor groups (p < 0.001). Second-line chemotherapy may be beneficial for OS in ESCC patients with ECOG PS 0-1 and PFS under first-line therapy >= 4 months. Copyright (C) 2011 S. Karger AG, Basel
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