The presence of CD8(+) invariant NKT cells in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Hong, Changwan | - |
dc.contributor.author | Shin, Junghoon | - |
dc.contributor.author | Oh, Soohwan | - |
dc.contributor.author | Jung, Sundo | - |
dc.contributor.author | Park, Yoon-Kyung | - |
dc.contributor.author | Hong, Seokmann | - |
dc.contributor.author | Lee, Gap Ryol | - |
dc.contributor.author | Park, Se-Ho | - |
dc.date.accessioned | 2021-09-08T10:36:02Z | - |
dc.date.available | 2021-09-08T10:36:02Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2009-12-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118723 | - |
dc.description.abstract | Invariant natural killer T (iNKT) cells develop in the thymus upon recognition of CD1d expressed on developing thymocytes. Although CD4 and CD8 coreceptors are not directly involved in the interaction between CD1d and the T cell receptors (TCRs) of iNKT cells, a conspicuous lack of CD8(+) iNKT cells in mice raised the question of whether CD8(+) iNKT cells are excluded due to negative selection during their thymic development, or if there is no lineage commitment for the development of murine CD8(+) iNKT cells. To address this question, we analyzed iNKT cell-specific TCR V alpha 14(+) transgenic mice, where the V alpha 14 transgene forces the generation of iNKT cells. This allows detailed study of the iNKT cell repertoire. We were able to identify CD8(+) iNKT cells which respond to the NKT cell-specific glycolipid ligand alpha-galactosylceramide. Unlike conventional iNKT cells, CD8(+) iNKT cells produce predominantly IFN-gamma but not IL-4 upon antigen stimulation. We also confirmed the presence of CD8(+) iNKT cells in wild type mice. Our results suggest that CD8(+) NKT cells do exist in mice, although their population size is quite small. Their Th1-skewed phenotype might explain why the population size of this subtype needs to be controlled tightly. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.subject | KILLER T-CELLS | - |
dc.subject | RECEPTOR | - |
dc.subject | RECOGNITION | - |
dc.subject | SELECTION | - |
dc.subject | SUBSETS | - |
dc.subject | CD69 | - |
dc.title | The presence of CD8(+) invariant NKT cells in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.3858/emm.2009.41.12.092 | - |
dc.identifier.scopusid | 2-s2.0-75149158479 | - |
dc.identifier.wosid | 000273334600003 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.41, no.12, pp.866 - 872 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 41 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 866 | - |
dc.citation.endPage | 872 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001402751 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | KILLER T-CELLS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | SELECTION | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | CD69 | - |
dc.subject.keywordAuthor | antigens, CD1d | - |
dc.subject.keywordAuthor | CD8-positive T-lymphocytes | - |
dc.subject.keywordAuthor | alpha-galactosylceramide | - |
dc.subject.keywordAuthor | mice, transgenic | - |
dc.subject.keywordAuthor | natural killer T-cells | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.