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Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

Authors
Na, Kyoung-SaeTae, Seong-HoSong, Jin-wonKim, Yong-Ku
Issue Date
Dec-2009
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Borna disease virus; Psychiatric disorders; Peripheral blood mononuclear cell; Real-time reverse transcriptase polymerase chain reaction
Citation
PSYCHIATRY INVESTIGATION, v.6, no.4, pp.306 - 312
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
PSYCHIATRY INVESTIGATION
Volume
6
Number
4
Start Page
306
End Page
312
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/118794
DOI
10.4306/pi.2009.6.4.306
ISSN
1738-3684
Abstract
Objective Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been Suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea. Methods We recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs). Results Neither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups. Conclusion Our results suggest that BDV might not be associated with psychiatric patients in Korea. Psychiatry Invest 2009;6:306-312
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