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Resolution of Pregabalin and Mirtazapine Associated Restless Legs Syndrome by Bupropion in a Patient with Major Depressive Disorder

Authors
Park, Young-MinLee, Heon-JeongKang, Seung-GulCho, Jae-HyuckKim, Leen
Issue Date
Dec-2009
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Restless legs syndrome; Bupropion; Pregabalin; Mirtazapine
Citation
PSYCHIATRY INVESTIGATION, v.6, no.4, pp 313 - 315
Pages
3
Indexed
SCIE
SCOPUS
KCICANDI
Journal Title
PSYCHIATRY INVESTIGATION
Volume
6
Number
4
Start Page
313
End Page
315
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/118813
DOI
10.4306/pi.2009.6.4.313
ISSN
1738-3684
1976-3026
Abstract
Bupropion is a selective norepinephrine and dopamine reuptake inhibitor with no serotonergic activity, and is therefore an antidepressant with unique pharmacological properties. There are some reports that selective serotonin reuptake inhibitors (SSRIs) or mirtazapine can induce adverse effects including restless legs syndrome (RLS) and that bupropion can reverse these adverse effects. Here, we report about a patient with a major depressive disorder who exhibited RLS after being treated with pregabalin and mirtazapine. This adverse effect disappeared after having switched from mirtazapine to bupropion. Bupropion inhibits the reuptake of dopamine and increases dopamine neurotransmission in both the nucleus accumbens and the prefrontal cortex. This pharmacological profile can be effective in patients with RLS related to dopamine hypoactivity. However, the limitations of this single case report mean that further investigations with larger samples are needed. Psychiatry Invest 2009;6:313-315
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