Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Functional polymorphism in manganese superoxide dismutase and antioxidant status: Their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer

Authors
Tong, Seo-YunLee, Jong-MinSong, Eun-SeopLee, Kwang-BeomKim, Mi-KyungLee, Jae-KwanSon, Sung-KyongLee, Jung-PilKim, Jae-HoonKwon, Yong-Il
Issue Date
11월-2009
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Manganese superoxide dismutase (MnSOD); Antioxidants; Polymorphism; Cervical cancer; Cervical intraepithelial neoplasia
Citation
GYNECOLOGIC ONCOLOGY, v.115, no.2, pp.272 - 276
Indexed
SCIE
SCOPUS
Journal Title
GYNECOLOGIC ONCOLOGY
Volume
115
Number
2
Start Page
272
End Page
276
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/119023
DOI
10.1016/j.ygyno.2009.07.032
ISSN
0090-8258
Abstract
Objective. Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, plays a key role in protecting cells from oxidative stress. Furthermore, the MnSOD rs4880 polymorphism is associated with enzyme activity. The authors evaluated the interaction between MnSOD genotypes and cervical carcinogenesis risk and the modulating effects of serum antioxidant nutrient status (beta-carotene, lycopene, zeaxanthin/lutein, retinol, alpha-tocopherol and gamma-tocopherol). Methods. Cases and controls for this study were recruited between June 2006 and July 2007 (263 controls, 84 cervical intraepithelial neoplasia (CIN), 94 CIN 2/3, and 99 cases of cervical cancer). The MnSOD polymorphism at rs4880T/C was examined using SNaPshot assays. Serum antioxidant vitamin concentrations were measured by reverse-phase gradient high-pressure liquid chromatography. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated after adjusting for age, menopause, parity, oral contraceptive use, smoking and alcohol Consumption. Results. No association was found between the MnSOD rs4880 polymorphism and cervical cancer. However, genotypes significantly modified the risk of cervical cancer in association with the serum statuses of micronutrients (P-interaction<0.05 for beta-carotene, lycopene, zeaxanthin/lutein, alpha-tocopherol, and gamma-tocopherol). Decreased CIN1 risk in association with the MnSOD rs4880 variant genotype was also observed particularly for subjects with higher beta-carotene and gamma-tocopherol levels. Similar results were observed for lycopene and alpha-tocopherol in relation to the risk of CIN2/3. Conclusion. Our findings suggest that a higher antioxidant micronutrients status may decrease the risk of CIN and cervical cancer and modify the effect of the MnSOD polymorphism on disease risk. (C) 2009 Published by Elsevier Inc.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Jae Kwan photo

Lee, Jae Kwan
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE