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Increased Transforming Growth Factor-beta1 in Alcohol Dependence
- Authors
- Kim, Yong-Ku; Lee, Boung Chul; Ham, Byung Joo; Yang, Byung-Hwan; Roh, Sungwon; Choi, Joonho; Kang, Tae-Cheon; Chai, Young-Gyu; Choi, Ihn-Geun
- Issue Date
- 10월-2009
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Alcohols; Transforming Growth Factor beta1
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.24, no.5, pp.941 - 944
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 24
- Number
- 5
- Start Page
- 941
- End Page
- 944
- ISSN
- 1011-8934
- Abstract
- Ethanol and its metabolite acetaldehyde increase transforming growth factor betal (TGF-beta 1) expression in animal studies. TGF-beta 1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-beta 1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-beta 1 levels in the patients with alcohol dependence (1,653.11 +/- 532.45 pg/mL) were significantly higher than those of healthy subjects (669.87 +/- 366.53 pg/mL) (P=4.000). Patients with or without liver pathology showed no difference in TGF-beta 1 (P=0.36). Increased TGF-beta 1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.
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