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Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review

Authors
Boo, Yoon-JungFisher, Jason C.Haley, Mary JoCowles, Robert A.Kandel, Jessica J.Yamashiro, Darrell J.
Issue Date
Oct-2009
Publisher
W B SAUNDERS CO-ELSEVIER INC
Keywords
Clear cell sarcoma of the kidney; Angiopoietin; Vascular endothelial growth factor; Notch; c-KIT
Citation
JOURNAL OF PEDIATRIC SURGERY, v.44, no.10, pp.2031 - 2036
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF PEDIATRIC SURGERY
Volume
44
Number
10
Start Page
2031
End Page
2036
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/119171
DOI
10.1016/j.jpedsurg.2009.06.023
ISSN
0022-3468
Abstract
Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of turner cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK turners may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature. (C) 2009 Elsevier Inc. All rights reserved.
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