Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonists on Myofibroblast Differentiation and Collagen Production in Nasal Polyp-Derived Fibroblasts
- Authors
- Lee, Heung-Man; Kang, Hee Jun; Park, Hyo Hun; Hong, Seok-Chan; Kim, Jin-Kook; Cho, Jae Hoon
- Issue Date
- 10월-2009
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- fibroblast; nasal polyp; peroxisome proliferator-activated receptor gamma agonist
- Citation
- ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, v.118, no.10, pp.721 - 727
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
- Volume
- 118
- Number
- 10
- Start Page
- 721
- End Page
- 727
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119227
- DOI
- 10.1177/000348940911801007
- ISSN
- 0003-4894
- Abstract
- Objectives: We investigated the effect of transforming growth factor-beta 1 (TGF-beta 1) on the differentiation of nasal polyp-derived Fibroblasts (NPDFs) and on their production of collagen, and investigated the effect of peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists on the effects of TGF-beta 1. Methods: Primary fibroblast lines were established from 5 human nasal polyp tissues. We activated the NPDFs with TGF-beta 1 and exposed them to the PPAR gamma agonists ciglitazone and 15-deoxy-Delta-prostaglandin J2. The expression of alpha-smooth muscle actin (alpha-SMA) and collagen was measured by reverse transcriptase-polymerase chain reactions, immunocytochemical staining, and collagen assays. Results: The treatment with TGF-beta 1 increased the expression of alpha-SMA and collagen, and expression was markedly attenuated by the PPAR gamma agonists. Conclusions: PPAR gamma agonists inhibit the differentiation of TGF-beta 1-activated NPDFs and their production of collagen.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.