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Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides

Authors
Youn, Ui JoungLee, Ye SeulJeong, HanaLee, JunNam, Joo-WonLee, Yoo JinHwang, Eun SookLee, Je-HyunLee, DonghoKang, Sam SikSeo, Eun-Kyoung
Issue Date
Oct-2009
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.72, no.10, pp.1895 - 1898
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NATURAL PRODUCTS
Volume
72
Number
10
Start Page
1895
End Page
1898
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/119228
DOI
10.1021/np900397f
ISSN
0163-3864
Abstract
Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 mu M.
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