Association between the rs2004640 functional polymorphism of interferon regulatory factor 5 and systemic lupus erythematosus: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-08T15:13:54Z | - |
dc.date.available | 2021-09-08T15:13:54Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119595 | - |
dc.description.abstract | The aim of this study is to determine whether the functional interferon regulatory factor 5 (IRF5) polymorphism, rs2004640, confers susceptibility to systemic lupus erythematosus (SLE) in multiple ethic populations. A meta-analysis was conducted on the T allele of the IRF5 rs2004640 polymorphism and 12 studies were included in the meta-analysis. Meta-analysis revealed an association between SLE and the IRF5 rs2004640 T allele in all subjects without inter-study heterogeneity (OR 1.429, 95% CI 1.359-1.503, P < 0.001). The IRF5 rs2004640 T allele was significantly associated with SLE in European and Asians. The Asian population had a much lower prevalence of the T allele (34.4%) than any other population studied. and Europeans had the highest frequency of the IRF5 rs2004640 T allele (51.8%). In conclusion, this meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | RISK HAPLOTYPE | - |
dc.subject | IRF5 | - |
dc.subject | VARIANTS | - |
dc.subject | GENE | - |
dc.subject | SLE | - |
dc.subject | POPULATION | - |
dc.subject | INDUCTION | - |
dc.subject | ISOFORMS | - |
dc.subject | ITGAM | - |
dc.subject | SCAN | - |
dc.title | Association between the rs2004640 functional polymorphism of interferon regulatory factor 5 and systemic lupus erythematosus: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s00296-008-0801-7 | - |
dc.identifier.scopusid | 2-s2.0-68149137024 | - |
dc.identifier.wosid | 000268501800003 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.29, no.10, pp.1137 - 1142 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 29 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1137 | - |
dc.citation.endPage | 1142 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | RISK HAPLOTYPE | - |
dc.subject.keywordPlus | IRF5 | - |
dc.subject.keywordPlus | VARIANTS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | ISOFORMS | - |
dc.subject.keywordPlus | ITGAM | - |
dc.subject.keywordPlus | SCAN | - |
dc.subject.keywordAuthor | IRF5 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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