Association between the rs2004640 functional polymorphism of interferon regulatory factor 5 and systemic lupus erythematosus: a meta-analysis
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- 8월-2009
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- IRF5; Polymorphism; Systemic lupus erythematosus; Meta-analysis
- Citation
- RHEUMATOLOGY INTERNATIONAL, v.29, no.10, pp.1137 - 1142
- Indexed
- SCIE
SCOPUS
- Journal Title
- RHEUMATOLOGY INTERNATIONAL
- Volume
- 29
- Number
- 10
- Start Page
- 1137
- End Page
- 1142
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119595
- DOI
- 10.1007/s00296-008-0801-7
- ISSN
- 0172-8172
- Abstract
- The aim of this study is to determine whether the functional interferon regulatory factor 5 (IRF5) polymorphism, rs2004640, confers susceptibility to systemic lupus erythematosus (SLE) in multiple ethic populations. A meta-analysis was conducted on the T allele of the IRF5 rs2004640 polymorphism and 12 studies were included in the meta-analysis. Meta-analysis revealed an association between SLE and the IRF5 rs2004640 T allele in all subjects without inter-study heterogeneity (OR 1.429, 95% CI 1.359-1.503, P < 0.001). The IRF5 rs2004640 T allele was significantly associated with SLE in European and Asians. The Asian population had a much lower prevalence of the T allele (34.4%) than any other population studied. and Europeans had the highest frequency of the IRF5 rs2004640 T allele (51.8%). In conclusion, this meta-analysis confirms that the IRF5 rs2004640 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
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