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Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men

Authors
Motoyama, Kenneth R.Curb, J. DavidKadowaki, TakashiEl-Saed, AimanAbbott, Robert D.Okamura, TomonoriEvans, Rhobert W.Nakamura, YasuyukiSutton-Tyrrell, KimRodriquez, Beatriz L.Kadota, AyaEdmundowicz, DanielWillcox, Bradley J.Choo, JinaKatsumi, NakataOtake, TeruoKadowaki, SayakaKuller, Lewis H.Ueshima, HirotusguSekikawa, Akira
Issue Date
1-7월-2009
Publisher
OXFORD UNIV PRESS
Citation
AMERICAN JOURNAL OF CLINICAL NUTRITION, v.90, no.1, pp.49 - 55
Indexed
SCIE
SCOPUS
Journal Title
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume
90
Number
1
Start Page
49
End Page
55
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/119688
DOI
10.3945/ajcn.2008.26761
ISSN
0002-9165
Abstract
Background: The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known. Objective: Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40 49 y. Design: We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used. Results: Serum n-6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [beta = -0.39 (P < 0.001), -0.38 (P < 0.001), and -0.33 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [beta = -0.15 (P < 0.001), -0.22 (P < 0.001), and -0.13 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (beta = 4.49, P < 0.001) and Japanese (beta = 3.73, P < 0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (beta = 2.15, P < 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (beta = 2.68, P < 0.01). Conclusion: Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations. Am J Clin Nutr 2009;90:49-55.
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