Fc gamma receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis
- Authors
- Lee, Y. H.; Ji, J. D.; Song, G. G.
- Issue Date
- Jul-2009
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Fc receptors; genetic polymorphism; meta-analysis; systemic lupus erythematosus
- Citation
- LUPUS, v.18, no.8, pp.727 - 734
- Indexed
- SCIE
SCOPUS
- Journal Title
- LUPUS
- Volume
- 18
- Number
- 8
- Start Page
- 727
- End Page
- 734
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119794
- DOI
- 10.1177/0961203309104020
- ISSN
- 0961-2033
- Abstract
- The aim of this study was to explore whether polymorphisms of the Fc gamma receptors (Fc gamma Rs) IIB T/I232 and Fc gamma RIIIB NA1/NA2, confer susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN). The authors conducted a meta-analysis on associations between the Fc gamma RIIB T/I232 and Fc gamma RIIIB NA1/NA2 polymorphisms and SLE and LN susceptibility as determined using 1) allele contrast, 2) recessive, 3) dominant models and 4) contrast of homozygotes. A total of 16 separate comparisons were considered, consisting of 2887 SLE patients and 3105 controls. Meta-analysis of the Fc gamma RIIB T/I232 polymorphism showed a significant association between the Fc gamma RIIB T allele and the risk of developing SLE compared with the Fc gamma RIIB I allele (OR = 1.207, 95% CI = 1.061-1.373, P = 0.004). In subjects of Asian descent, a significant association was observed between the Fc gamma RIIB T allele and SLE (OR = 1.332, 95% CI 1.138-1.558, P < 0.001). However, in Europeans no such association was found. In contrast, no association was found between SLE or LN and the Fc gamma RIIIB NA1/NA2 polymorphism in all subjects, or in European and Asian populations. This meta-analysis shows that the Fc gamma RIIB T/I232 polymorphism confers susceptibility to SLE, especially in Asian-derived populations. Lupus (2009) 18, 727-734.
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