Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing
- Authors
- Yaqoob, Zahid; Choi, Wonshik; Oh, Seungeun; Lue, Niyom; Park, Yongkeun; Fang-Yen, Christopher; Dasari, Ramachandra R.; Badizadegan, Kamran; Feld, Michael S.
- Issue Date
- 22-6월-2009
- Publisher
- OPTICAL SOC AMER
- Citation
- OPTICS EXPRESS, v.17, no.13, pp.10681 - 10687
- Indexed
- SCIE
SCOPUS
- Journal Title
- OPTICS EXPRESS
- Volume
- 17
- Number
- 13
- Start Page
- 10681
- End Page
- 10687
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119812
- DOI
- 10.1364/OE.17.010681
- ISSN
- 1094-4087
- Abstract
- We report a quantitative phase microscope based on spectral domain optical coherence tomography and line-field illumination. The line illumination allows self phase-referencing method to reject common-mode phase noise. The quantitative phase microscope also features a separate reference arm, permitting the use of high numerical aperture (NA > 1) microscope objectives for high resolution phase measurement at multiple points along the line of illumination. We demonstrate that the path-length sensitivity of the instrument can be as good as 41 pm / root Hz, which makes it suitable for nanometer scale study of cell motility. We present the detection of natural motions of cell surface and two-dimensional surface profiling of a HeLa cell. (C) 2009 Optical Society of America
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Collections - College of Science > Department of Physics > 1. Journal Articles
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