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Synthesis of a Novel Series of Imidazo[1,2-alpha]pyridines as Acyl-CoA: Cholesterol Acyltransferase (ACAT) Inhibitors
- Authors
- Jin, Yinglan; Rho, Mun-Chual; Gajulapati, Kondaji; Jung, Hwa Young; Boovanahalli, Shanthaveerappa K.; Lee, Jee Hyun; Song, Gyu-Yong; Choi, Jung Ho; Kim, Young Kook; Lee, Kyeong; Choi, Yongseok
- Issue Date
- 20-6월-2009
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Imidazo[1,2-alpha]pyridines; Acyl CoA: cholestrol acyl transferase (ACAT); HepG2 cells; Structure-activity relationship
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.30, no.6, pp.1297 - 1304
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 30
- Number
- 6
- Start Page
- 1297
- End Page
- 1304
- ISSN
- 0253-2964
- Abstract
- A novel series of imidazo[1,2-alpha]pyridines was designed, synthesized, and tested for their ability to inhibit acyl-CoA:cholesterol acyltransferase. Preliminary lead optimization efforts resulted in the identification of ACAT inhibitors represented by analogues 5b, 5c, 6a, 6c, 7b, and 7c. The ACAT inhibitory activity of these compounds was further established by potent inhibition of cholesteryl ester formation in HepG2 cells by a representative analogue 7b.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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