Antimalarial Drug Susceptibility of Plasmodium vivax in the Republic of Korea
- Authors
- Chotivanich, Kesinee; Sattabongkot, Jetsumon; Choi, Yien Kyong; Park, Jae Sun; Sritabal, Juntima; Lim, Chae Seung; Udomsangpetch, Rachanee; White, Nicholas J.; Lee, Won Ja
- Issue Date
- 6월-2009
- Publisher
- AMER SOC TROP MED & HYGIENE
- Citation
- AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.80, no.6, pp.902 - 904
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Volume
- 80
- Number
- 6
- Start Page
- 902
- End Page
- 904
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119866
- DOI
- 10.4269/ajtmh.2009.80.902
- ISSN
- 0002-9637
- Abstract
- The antimalarial susceptibility of ring stage (> 80%) Plasmodium vivax from the Republic of Korea, where long incubation-period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005-2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC50) were quinine 60 (54-75) ng/mL, chloroquine 39 (22-282) ng/mL, piperaquine 27 (17-58) ng/mL, mefloquine 39 (35-67) ng/mL. pyrimethamine 138 (89-280) ng/mL, artesunate 0.6 (0.5-0.8) ng/mL, and primaquine 122 (98-232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6 P = 0.004), piperaquine and chloroquine (r = 0.6 P = 0.008), and piperaquine and primaquine IC50 values (r = 0.5, P = 0.01). Compared with P vivax in Thailand, P. vivax in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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