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Regulation of Adiponectin Receptor 2 Expression via PPAR-alpha in NIT-1 Cells
- Authors
- Jung, Tae Woo; Lee, Myung Won; Lee, Yong Jik; Kim, Seon Mee; Lee, Kyoung Tae; Whang, Wan Kyunn; Cheon, Hwan Ju; Jeong, Yeon Taek; Chung, Kun Wook; Cho, Jae Min; Kim, Do Hoon; Jung, Tae Woo
- Issue Date
- Jun-2009
- Publisher
- JAPAN ENDOCRINE SOC
- Keywords
- Adiponectin receptor 2; peroxisome proliferator-activated receptor-alpha; beta cells; Clofibrate; palmitate
- Citation
- ENDOCRINE JOURNAL, v.56, no.3, pp.377 - 382
- Indexed
- SCIE
SCOPUS
- Journal Title
- ENDOCRINE JOURNAL
- Volume
- 56
- Number
- 3
- Start Page
- 377
- End Page
- 382
- ISSN
- 0918-8959
- Abstract
- Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in beta cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in beta cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened beta cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-alpha; this delay was abolished by PPAR-alpha targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-alpha.
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Related Researcher
- Kim, Seon Mee
- College of Medicine (Department of Medical Science)