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Regulation of Adiponectin Receptor 2 Expression via PPAR-alpha in NIT-1 Cells

Authors
Jung, Tae WooLee, Myung WonLee, Yong JikKim, Seon MeeLee, Kyoung TaeWhang, Wan KyunnCheon, Hwan JuJeong, Yeon TaekChung, Kun WookCho, Jae MinKim, Do HoonJung, Tae Woo
Issue Date
Jun-2009
Publisher
JAPAN ENDOCRINE SOC
Keywords
Adiponectin receptor 2; peroxisome proliferator-activated receptor-alpha; beta cells; Clofibrate; palmitate
Citation
ENDOCRINE JOURNAL, v.56, no.3, pp.377 - 382
Indexed
SCIE
SCOPUS
Journal Title
ENDOCRINE JOURNAL
Volume
56
Number
3
Start Page
377
End Page
382
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/119930
DOI
10.1507/endocrj.K08E-354
ISSN
0918-8959
Abstract
Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in beta cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in beta cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened beta cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-alpha; this delay was abolished by PPAR-alpha targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-alpha.
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