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Inhibitory Effect of Poncirus trifoliate on Acetylcholinesterase and Attenuating Activity against Trimethyltin-Induced Learning and Memory Impairment

Authors
Kim, Jae KyeomBae, HeyriKim, Mi-JeongChoi, Soo JungCho, Hong YonHwang, Han-JoonKim, Young JunLim, Seung TaikKim, Eun KiKim, Hye KyungKim, Bok YongShin, Dong-Hoon
Issue Date
5월-2009
Publisher
TAYLOR & FRANCIS LTD
Keywords
methoxsalen (8-methoxy-2 ' ,3 ' ,6,7-furocoumarin); Poncirus trifoliate; Alzheimer' s disease; acetylcholinesterase; amyloid beta peptide
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.73, no.5, pp.1105 - 1112
Indexed
SCIE
SCOPUS
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
73
Number
5
Start Page
1105
End Page
1112
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120083
DOI
10.1271/bbb.80859
ISSN
0916-8451
Abstract
Various native Korean plants were screened to find an effective acetyleholinesterase (AChE) inhibitor for the treatment of Alzheimer's disease (AD). Among these plants, the ethanol extract of Poncirus trifoliate was selected for isolating the AChE inhibitor because it exhibited the highest inhibitory activity (47.31%). To separate the active compound from Poncirus trifoliate, solvent partition, open column chromatography, thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) were utilized. The putative chemical structure of the AChE inhibitor was identified as methoxsalen by successive analysis with electron ionization mass spectrometry (EI-MS) and C-13/H-1-nuclear magnetic resonance (NMR). To confirm the attenuating effect of the Poncirus trifoliate extract against trimethyltin (TMT)-induced neurotoxicity, in vivo behavior tests were carried out. Our findings suggest that the Poncirus trifoliate extract significantly reversed TMT-induced learning and memory impairment. These results demonstrate that the Poncirus trifoliate extract could possess a wide range of beneficial activities for neurodegenerative disorders, notably AD.
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