Anticancer activity of lactoferrin isolated from caprine colostrum on human cancer cell lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Younghoon | - |
dc.contributor.author | Kim, Mae Jin | - |
dc.contributor.author | Han, Kyoung Sik | - |
dc.contributor.author | Imm, Jee Young | - |
dc.contributor.author | Oh, Sejong | - |
dc.contributor.author | Kim, Sae Hun | - |
dc.date.accessioned | 2021-09-08T17:32:48Z | - |
dc.date.available | 2021-09-08T17:32:48Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 1364-727X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120121 | - |
dc.description.abstract | In the present study, lactoferrin was purified from caprine colostrum and its anticancer effects were investigated on various cancer cell lines, including lung, colon, cervix, stomach and breast cancer cells. The caprine lactoferrin (CLF) was purified by ultrafiltration and sequential chromatography using a CM-Sephadex C-50-120 ion-exchange column and affinity chromatography on Hi-Trap(TM) Heparin HP. The purified CLF exhibited antiproliferative effects on the five tested cancer cell lines in a dose-dependent manner, with 20-30% survival as compared to the control. Interestingly, the most intense inhibition of cell growth was observed on the ZR-75-1 breast cancer cells (IC50 = 27.5 mu g/mL). Our findings suggest, for the first time, that purified CLF from caprine colostrum may constitute a novel anticancer agent for the food industry. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | NATIVE GOAT LACTOFERRIN | - |
dc.subject | BOVINE LACTOFERRIN | - |
dc.subject | ANTIBACTERIAL PEPTIDES | - |
dc.subject | IN-VITRO | - |
dc.subject | SEQUENCE | - |
dc.subject | BINDING | - |
dc.title | Anticancer activity of lactoferrin isolated from caprine colostrum on human cancer cell lines | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sae Hun | - |
dc.identifier.doi | 10.1111/j.1471-0307.2009.00466.x | - |
dc.identifier.scopusid | 2-s2.0-66149103175 | - |
dc.identifier.wosid | 000266268100022 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, v.62, no.2, pp.277 - 281 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY | - |
dc.citation.volume | 62 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 277 | - |
dc.citation.endPage | 281 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | NATIVE GOAT LACTOFERRIN | - |
dc.subject.keywordPlus | BOVINE LACTOFERRIN | - |
dc.subject.keywordPlus | ANTIBACTERIAL PEPTIDES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | Caprine lactoferrin | - |
dc.subject.keywordAuthor | Chromatography | - |
dc.subject.keywordAuthor | Purification | - |
dc.subject.keywordAuthor | Human cancer cell lines | - |
dc.subject.keywordAuthor | Anticancer activity | - |
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