Effects of Yeast Hydrolysate on Neuropeptide Y (NPY) and Tryptophan Hydroxylase (TPH) Immunoreactivity in Rats
DC Field | Value | Language |
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dc.contributor.author | Jung, Eun Young | - |
dc.contributor.author | Kang, Duk Ho | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Chang, Un-Jae | - |
dc.date.accessioned | 2021-09-08T17:37:46Z | - |
dc.date.available | 2021-09-08T17:37:46Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120147 | - |
dc.description.abstract | To investigate the appetite regulation mechanism of low and high molecular weight yeast hydrolysate, neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) expressions were analyzed in the brains on rats using immunohistochemical method; normal diet (control), 0.1 g/kg (BY-1) or 1.0 g/kg (BY-2) of yeast hydrolysate below 10 kDa, 0.1 g/kg (AY-1) or 1.0 g/kg (AY-2) of yeast hydrolysate of 10-30 kDa. Body weight gain was lower in the BY-2 (133.0 g) than in the control (150.1 g) (p < 0.05). Triacylglyceride, total cholesterol, and LDL-cholesterol levels were lower in the BY-2 as compared to control, BY-1. and AY-2 (p < 0.05). NPY staining intensities at paraventricular nucleus (PVN) were lower in the BY groups (BY-1: 96.1, BY-2: 88.6) as compared to the control (105.6) and AY groups (AY-1: 110.5, AY-2:114.1) (p < 0.05). NPY expression at lateral hypothalamic area (LHA) was lower in the BY-2 (92.3) than in the control (98.9) (p < 0.05). The BY groups (BY-1: 143.9, BY-2: 154.6) had higher TPH staining intensities at dorsal raphe (DR) than the AY-2 (115.9) (p < 0.05). In conclusion, the results indicate that administering yeast hydrolysate of below 10 kDa to normal diet-fed rats reduced body weight gain and serum lipids by altering NPY and TPH expressions. Copyright (C) 2008 John Wiley & Sons, Ltd. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | BODY-FAT | - |
dc.subject | HYPOTHALAMUS | - |
dc.subject | NUCLEUS | - |
dc.subject | NEURONS | - |
dc.subject | OBESE | - |
dc.title | Effects of Yeast Hydrolysate on Neuropeptide Y (NPY) and Tryptophan Hydroxylase (TPH) Immunoreactivity in Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Eun Young | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.identifier.doi | 10.1002/ptr.2668 | - |
dc.identifier.scopusid | 2-s2.0-65649108039 | - |
dc.identifier.wosid | 000265986800005 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.23, no.5, pp.619 - 623 | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 23 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 619 | - |
dc.citation.endPage | 623 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | BODY-FAT | - |
dc.subject.keywordPlus | HYPOTHALAMUS | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | OBESE | - |
dc.subject.keywordAuthor | yeast hydrolysate | - |
dc.subject.keywordAuthor | neuropeptide Y | - |
dc.subject.keywordAuthor | tryptophan hydroxylase | - |
dc.subject.keywordAuthor | anti-obesity | - |
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