Neuroprotective and Neurotrophic Effects of Isorosmanol
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, So-Young | - |
dc.date.accessioned | 2021-09-08T17:41:30Z | - |
dc.date.available | 2021-09-08T17:41:30Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 0939-5075 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120166 | - |
dc.description.abstract | The neurotoxicity induced by beta-amyloid (A beta), which is one of the major causes of Alzheimer's disease (AD), leads to synaptic loss and subsequent neuronal death. Therefore, modulation of A,beta-induced neurotoxicity, as well as regeneration of damaged synapses could be important therapeutic approaches to control AD. In this study, we found that isorosmanol, an abietane-type diterpene, protected PC12 cells against A beta-induced toxicity. Furthermore, isorosmanol promoted the generation of neurites. The neurotrophic effect of isorosmanol was enhanced by co-treatment with nerve growth factor (NGF). In addition, the neurite outgrowth induced by isorosmanol was accompanied by F-actin redistribution and increased expression of neurofilaments. Taken together, these results suggest that isorosmanol possesses both neuroprotective and neurotrophic effects, that might be beneficial for controlling AD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | VERLAG Z NATURFORSCH | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | PC12 CELLS | - |
dc.subject | MATURATION | - |
dc.subject | TOXICITY | - |
dc.subject | PROTEIN | - |
dc.title | Neuroprotective and Neurotrophic Effects of Isorosmanol | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, So-Young | - |
dc.identifier.scopusid | 2-s2.0-70349304412 | - |
dc.identifier.wosid | 000268826700016 | - |
dc.identifier.bibliographicCitation | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v.64, no.5-6, pp.395 - 398 | - |
dc.relation.isPartOf | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | - |
dc.citation.title | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | - |
dc.citation.volume | 64 | - |
dc.citation.number | 5-6 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 398 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PC12 CELLS | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Isorosmanol | - |
dc.subject.keywordAuthor | Neurotrophic Effect | - |
dc.subject.keywordAuthor | Beta-amyloid | - |
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