Neuroprotective and Neurotrophic Effects of Isorosmanol
- Authors
- Park, So-Young
- Issue Date
- 5월-2009
- Publisher
- VERLAG Z NATURFORSCH
- Keywords
- Isorosmanol; Neurotrophic Effect; Beta-amyloid
- Citation
- ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v.64, no.5-6, pp.395 - 398
- Indexed
- SCIE
SCOPUS
- Journal Title
- ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
- Volume
- 64
- Number
- 5-6
- Start Page
- 395
- End Page
- 398
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120166
- ISSN
- 0939-5075
- Abstract
- The neurotoxicity induced by beta-amyloid (A beta), which is one of the major causes of Alzheimer's disease (AD), leads to synaptic loss and subsequent neuronal death. Therefore, modulation of A,beta-induced neurotoxicity, as well as regeneration of damaged synapses could be important therapeutic approaches to control AD. In this study, we found that isorosmanol, an abietane-type diterpene, protected PC12 cells against A beta-induced toxicity. Furthermore, isorosmanol promoted the generation of neurites. The neurotrophic effect of isorosmanol was enhanced by co-treatment with nerve growth factor (NGF). In addition, the neurite outgrowth induced by isorosmanol was accompanied by F-actin redistribution and increased expression of neurofilaments. Taken together, these results suggest that isorosmanol possesses both neuroprotective and neurotrophic effects, that might be beneficial for controlling AD.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.