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A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

Authors
Cho, Yoon ShinGo, Min JinKim, Young JinHeo, Jee YeonOh, Ji HeeBan, Hyo-JeongYoon, DankyuLee, Mi HeeKim, Dong-JoonPark, MieyCha, Seung-HunKim, Jun-WooHan, Bok-GheeMin, HaesookAhn, YounjhinPark, Man SukHan, Hye ReeJang, Hye-YoonCho, Eun YoungLee, Jong-EunCho, Nam H.Shin, CholPark, TaesungPark, Ji WanLee, Jong-KeukCardon, LonClarke, GeraldineMcCarthy, Mark I.Lee, Jong-YoungLee, Jong-KooOh, BermseokKim, Hyung-Lae
Issue Date
5월-2009
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE GENETICS, v.41, no.5, pp.527 - 534
Indexed
SCIE
SCOPUS
Journal Title
NATURE GENETICS
Volume
41
Number
5
Start Page
527
End Page
534
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120189
DOI
10.1038/ng.357
ISSN
1061-4036
Abstract
To identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples from population-based cohorts recruited in Korea. For height and body mass index, most variants detected overlapped those reported in European samples. For the other traits examined, replication of promising GWAS signals in 7,861 independent Korean samples identified six previously unknown loci. For pulse rate, signals reaching genome-wide significance mapped to chromosomes 1q32 (rs12731740, P = 2.9 x 10(-9)) and 6q22 (rs12110693, P = 1.6 x 10(-9)), with the latter similar to 400 kb from the coding sequence of GJA1. For systolic blood pressure, the most compelling association involved chromosome 12q21 and variants near the ATP2B1 gene (rs17249754, P = 1.3 x 10(-7)). For waist-hip ratio, variants on chromosome 12q24 (rs2074356, P = 7.8 x 10(-12)) showed convincing associations, although no regional transcript has strong biological candidacy. Finally, we identified two loci influencing bone mineral density at multiple sites. On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 x 10(-11)), tibia (P = 1.6 x 10(-6)) and heel (P = 1.9 x 10(-10)). On chromosome 7p14, rs1721400 (mapping close to SFRP4, a frizzled protein gene) showed consistent associations at the same three sites (P = 2.2 x 10(-3), P = 1.4 x 10(-7) and P = 6.0 x 10(-4), respectively). This large-scale GWA analysis of well-characterized Korean population-based samples highlights previously unknown biological pathways.
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