Fingerprinting Differentiation of Astragalus membranaceus Roots According to Ages Using H-1-NMR Spectroscopy and Multivariate Statistical Analysis
- Authors
- Shin, Yoo-Soo; Bang, Kyong-Hwan; In, Dong-Su; Sung, Jung-Sook; Kim, Seon-Young; Ku, Bon Cho; Kim, Suk-Weon; Lee, Dongho; Choi, Hyung-Kyoon
- Issue Date
- 30-4월-2009
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Fingerprinting analysis; Astragalus membranaceus; H-1 NMR spectroscopy; Principal component analysis; Canonical discriminant analysis
- Citation
- BIOMOLECULES & THERAPEUTICS, v.17, no.2, pp.133 - 137
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 17
- Number
- 2
- Start Page
- 133
- End Page
- 137
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120194
- DOI
- 10.4062/biomolther.2009.17.2.133
- ISSN
- 1976-9148
- Abstract
- The root of Astragalus membranaceus is a traditional folk medicine that has been used for many therapeutic purposes in Asia. It reportedly acts as an immunostimulant, tonic, hepatoprotective, diuretic, antidiabetic, analgesic, expectorant, sedative, and anticancer drug. In this study, metabolomic profiling was applied to the roots of A. membranaceus of different ages using NMR coupled with two multivariate statistical analysis methods: such as principal components analysis (PCA) and canonical discriminant analysis (CDA). This allowed various metabolites to be assigned in NMR spectra, including gamma-aminobutyric acid (GABA), aspartic acid, succinic acid, glutamic acid, glutamine, N-acetyl aspartic acid, acetic acid, arginine, alanine, threonine, lactic acid, and valine. The score plot from PCA and also CDA allowed a clear separation between samples according to age.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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