Runx3 inhibits IL-4 production in T cells via physical interaction with NFAT
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Ho | - |
dc.contributor.author | Jeong, Hyung Min | - |
dc.contributor.author | Choi, Jin Myung | - |
dc.contributor.author | Cho, Young-Chang | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.contributor.author | Lee, Kwang Youl | - |
dc.contributor.author | Kang, Bok Yun | - |
dc.date.accessioned | 2021-09-08T18:12:30Z | - |
dc.date.available | 2021-09-08T18:12:30Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-04-03 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120253 | - |
dc.description.abstract | Interleukin (IL)-4 plays a key role in T helper 2 (Th2) cell differentiation favoring humoral immune response. Regulation of IL-4 gene expression, therefore, is critically important for Th2 dependent responses and Th2 dominant disorders. In T cells, IL-4 gene expression is regulated positively or negatively by a combination of several transcription factors. Recently, enhanced IL-4 production was reported in Runx3 knockout mice; this implies negative regulation of IL-4 by Runx3. Runx proteins are transcription factors that have a Runt domain and have essential functions in development. In this Study, the molecular mechanism that downregulates IL-4 expression was investigated. Runx3 inhibited IL-4 production in EL-4 T cells stimulated with PMA/ionomycin. Runx3-mediated IL-4 inhibition was NFAT-dependent, and Runx3 was physically associated with NFAT. Therefore, our results suggest that the interaction between NFAT and Runx3 is a mechanism that causes the negative regulation of IL-4, along with previously reported repression by T-bet. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | INTERLEUKIN-4 GENE-EXPRESSION | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | NUCLEAR FACTOR | - |
dc.subject | FAMILY PROTEINS | - |
dc.subject | KAPPA-B | - |
dc.subject | ROLES | - |
dc.subject | INVOLVEMENT | - |
dc.subject | REGULATORS | - |
dc.subject | ELEMENTS | - |
dc.subject | LINEAGE | - |
dc.title | Runx3 inhibits IL-4 production in T cells via physical interaction with NFAT | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.02.026 | - |
dc.identifier.scopusid | 2-s2.0-61849090317 | - |
dc.identifier.wosid | 000264455900016 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.381, no.2, pp.214 - 217 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 381 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 214 | - |
dc.citation.endPage | 217 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | INTERLEUKIN-4 GENE-EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | NUCLEAR FACTOR | - |
dc.subject.keywordPlus | FAMILY PROTEINS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | REGULATORS | - |
dc.subject.keywordPlus | ELEMENTS | - |
dc.subject.keywordPlus | LINEAGE | - |
dc.subject.keywordAuthor | Runx3 | - |
dc.subject.keywordAuthor | NFAT | - |
dc.subject.keywordAuthor | IL-4 | - |
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