Runx3 inhibits IL-4 production in T cells via physical interaction with NFAT
- Authors
- Lee, Sung Ho; Jeong, Hyung Min; Choi, Jin Myung; Cho, Young-Chang; Kim, Tae Sung; Lee, Kwang Youl; Kang, Bok Yun
- Issue Date
- 3-4월-2009
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- Runx3; NFAT; IL-4
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.381, no.2, pp.214 - 217
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 381
- Number
- 2
- Start Page
- 214
- End Page
- 217
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120253
- DOI
- 10.1016/j.bbrc.2009.02.026
- ISSN
- 0006-291X
- Abstract
- Interleukin (IL)-4 plays a key role in T helper 2 (Th2) cell differentiation favoring humoral immune response. Regulation of IL-4 gene expression, therefore, is critically important for Th2 dependent responses and Th2 dominant disorders. In T cells, IL-4 gene expression is regulated positively or negatively by a combination of several transcription factors. Recently, enhanced IL-4 production was reported in Runx3 knockout mice; this implies negative regulation of IL-4 by Runx3. Runx proteins are transcription factors that have a Runt domain and have essential functions in development. In this Study, the molecular mechanism that downregulates IL-4 expression was investigated. Runx3 inhibited IL-4 production in EL-4 T cells stimulated with PMA/ionomycin. Runx3-mediated IL-4 inhibition was NFAT-dependent, and Runx3 was physically associated with NFAT. Therefore, our results suggest that the interaction between NFAT and Runx3 is a mechanism that causes the negative regulation of IL-4, along with previously reported repression by T-bet. (C) 2009 Elsevier Inc. All rights reserved.
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