Effects of Aucubin Isolated from Eucommia ulmoides on UVB-induced Oxidative Stress in Human Keratinocytes HaCaT
DC Field | Value | Language |
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dc.contributor.author | Ho, Jin Nyoung | - |
dc.contributor.author | Cho, Hong Yon | - |
dc.contributor.author | Lim, Eun Jeong | - |
dc.contributor.author | Kim, Hye Kyung | - |
dc.date.accessioned | 2021-09-08T18:21:17Z | - |
dc.date.available | 2021-09-08T18:21:17Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120298 | - |
dc.description.abstract | Ultraviolet B (UVB) radiation provokes the generation of reactive oxygen species (ROS) in the cells and skin, which induce oxidative stress in the exposed cells, leading to photoaging and cancer. Using the human keratinocytes HaCaT cell line, we investigated the photoprotective effects of aucubin isolated from Eucommia ulmoides. Pretreatment with aucubin markedly suppressed UVB-induced oxidative stress, which manifests as a decrease in intracellular lipid peroxidation, elevation of catalase activity, and reduced glutathione content. In addition, aucubin significantly reduced expression of matrix metalloproteinase-1 (MMP-1) protein (54%) and mRNA. Taken together, these results suggest that aucubin may offer protection against UVB-induced oxidative stress and may be used as a potential agent in prevention of UVB-induced photoaging. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.subject | MATRIX METALLOPROTEINASE-1 | - |
dc.subject | LIPID-PEROXIDATION | - |
dc.subject | ULTRAVIOLET-RADIATION | - |
dc.subject | SUPEROXIDE-DISMUTASE | - |
dc.subject | EXPRESSION | - |
dc.subject | OXYGEN | - |
dc.subject | ACID | - |
dc.subject | FIBROBLASTS | - |
dc.subject | IRRADIATION | - |
dc.subject | ACTIVATION | - |
dc.title | Effects of Aucubin Isolated from Eucommia ulmoides on UVB-induced Oxidative Stress in Human Keratinocytes HaCaT | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Hong Yon | - |
dc.identifier.scopusid | 2-s2.0-79954545027 | - |
dc.identifier.wosid | 000265748900032 | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.18, no.2, pp.475 - 480 | - |
dc.relation.isPartOf | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 475 | - |
dc.citation.endPage | 480 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001339057 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASE-1 | - |
dc.subject.keywordPlus | LIPID-PEROXIDATION | - |
dc.subject.keywordPlus | ULTRAVIOLET-RADIATION | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | IRRADIATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | photoaging | - |
dc.subject.keywordAuthor | ultraviolet B (UVB) | - |
dc.subject.keywordAuthor | aucubin | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | matrix metalloproteinase-1 (MMP-1) | - |
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