Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women
DC Field | Value | Language |
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dc.contributor.author | Choi, K. M. | - |
dc.contributor.author | Kim, T. N. | - |
dc.contributor.author | Yoo, H. J. | - |
dc.contributor.author | Lee, K. W. | - |
dc.contributor.author | Cho, G. J. | - |
dc.contributor.author | Hwang, T. G. | - |
dc.contributor.author | Baik, S. H. | - |
dc.contributor.author | Choi, D. S. | - |
dc.contributor.author | Kim, S. M. | - |
dc.date.accessioned | 2021-09-08T18:22:41Z | - |
dc.date.available | 2021-09-08T18:22:41Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.issn | 0300-0664 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120305 | - |
dc.description.abstract | Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Obese women exhibited higher A-FABP levels compared to nonobese women (21.4 +/- 6.4 mu g/l vs. 13.6 +/- 4.4 mu g/l, P < 0.001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0.054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21.4 +/- 6.4 mu g/l to 19.3 +/- 6.8 mu g/l (P = 0.038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | ACID-BINDING PROTEIN | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | RETINOL-BINDING-PROTEIN-4 LEVELS | - |
dc.subject | GLUCOSE | - |
dc.subject | BIOMARKER | - |
dc.subject | AP2 | - |
dc.title | Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, K. M. | - |
dc.contributor.affiliatedAuthor | Baik, S. H. | - |
dc.contributor.affiliatedAuthor | Choi, D. S. | - |
dc.contributor.affiliatedAuthor | Kim, S. M. | - |
dc.identifier.doi | 10.1111/j.1365-2265.2008.03374.x | - |
dc.identifier.scopusid | 2-s2.0-61449115949 | - |
dc.identifier.wosid | 000263856300011 | - |
dc.identifier.bibliographicCitation | CLINICAL ENDOCRINOLOGY, v.70, no.4, pp.569 - 574 | - |
dc.relation.isPartOf | CLINICAL ENDOCRINOLOGY | - |
dc.citation.title | CLINICAL ENDOCRINOLOGY | - |
dc.citation.volume | 70 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 569 | - |
dc.citation.endPage | 574 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | ACID-BINDING PROTEIN | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | RETINOL-BINDING-PROTEIN-4 LEVELS | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | AP2 | - |
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