Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women
- Authors
- Choi, K. M.; Kim, T. N.; Yoo, H. J.; Lee, K. W.; Cho, G. J.; Hwang, T. G.; Baik, S. H.; Choi, D. S.; Kim, S. M.
- Issue Date
- 4월-2009
- Publisher
- WILEY
- Citation
- CLINICAL ENDOCRINOLOGY, v.70, no.4, pp.569 - 574
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL ENDOCRINOLOGY
- Volume
- 70
- Number
- 4
- Start Page
- 569
- End Page
- 574
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120305
- DOI
- 10.1111/j.1365-2265.2008.03374.x
- ISSN
- 0300-0664
- Abstract
- Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding protein 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. We have evaluated the effect of exercise training on lipocalin family proteins and inflammatory markers. Thirty obese Korean women and 15 age-matched nonobese control subjects were studied. Concentrations of the lipocalin family proteins were compared between obese and nonobese women and were evaluated before and 3 months after an exercise programme consisting of aerobic exercise (45 min/session, 300 kcal/day) and muscle strength training (20 min/session, 100 kcal/day) five times a week. Obese women exhibited higher A-FABP levels compared to nonobese women (21.4 +/- 6.4 mu g/l vs. 13.6 +/- 4.4 mu g/l, P < 0.001). However, neither lipocalin-2 nor RBP4 levels were significantly different between the two groups, although the difference in lipocalin-2 was marginally significant (P = 0.054). Circulating A-FABP levels were significantly associated with body mass index (BMI), waist circumference, triglyceride, alanine aminotransferase (ALT), lipocalin-2 and high-sensitivity C-reactive protein (hsCRP) levels. After 3 months of the exercise training programme, serum A-FABP levels decreased significantly from 21.4 +/- 6.4 mu g/l to 19.3 +/- 6.8 mu g/l (P = 0.038), along with a reduction in weight, BMI, waist circumference, fasting glucose and total cholesterol levels. There was no significant change in the lipocalin-2 and RBP4 levels, although IL-6 levels increased after the exercise programme. Exercise training with weight loss induced a significant reduction in circulating A-FABP levels in obese Korean women.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.