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Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres
- Authors
- Lee, Sangyeop; Chon, Hyangah; Lee, Moonkwon; Choo, Jaebum; Shin, Soon Young; Lee, Young Han; Rhyu, Im Joo; Son, Sang Wook; Oh, Chil Hwan
- Issue Date
- 15-3월-2009
- Publisher
- ELSEVIER ADVANCED TECHNOLOGY
- Keywords
- Hollow gold nanosphere; Surface-enhanced Raman scattering; Cellular imaging; Cancer marker; Homogeneous sensing probe
- Citation
- BIOSENSORS & BIOELECTRONICS, v.24, no.7, pp.2260 - 2263
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSENSORS & BIOELECTRONICS
- Volume
- 24
- Number
- 7
- Start Page
- 2260
- End Page
- 2263
- ISSN
- 0956-5663
- Abstract
- Anti body-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells. (C) 2008 Elsevier B.V. All rights reserved.
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