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Silver-ion-mediated reactive oxygen species generation affecting bactericidal activity

Authors
Park, Hee-JinKim, Jee YeonKim, JaeeunLee, Joon-HeeHahn, Ji-SookGu, Man BockYoon, Jeyong
Issue Date
Mar-2009
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Silver; ROS (reactive oxygen species); Bactericidal; Superoxide; E. coli; S. aureus
Citation
WATER RESEARCH, v.43, no.4, pp.1027 - 1032
Indexed
SCIE
SCOPUS
Journal Title
WATER RESEARCH
Volume
43
Number
4
Start Page
1027
End Page
1032
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120466
DOI
10.1016/j.watres.2008.12.002
ISSN
0043-1354
Abstract
Silver ions have been widely used as disinfectants that inhibit bacterial growth by inhibiting the essential enzymatic functions of the microorganism via interaction with the thiol-group of L-cysteine. However, silver-ion-mediated perturbation of the bacterial respiratory chain has raised the possibility of reactive oxygen species (ROS) generation. We used bacterial reporter strains specifically responding to superoxide radicals and found that silver-ion-mediated ROS-generation affected bactericidal activity. Almost half the log reduction in Escherichia coli and Staphylococcus aureus populations (model strains for gram negative and positive bacteria, respectively) caused by silver-ion disinfection was attributed to ROS-mediated bactericidal activity. The major form of ROS generated was the superoxide-radical; H2O2 was not induced. Furthermore, silver ions strongly enhanced paraquat-induced oxidative stress, indicating close correlation and synergism between the conventional and ROS-mediated silver toxicity. Our results suggest that further studies in silver-based disinfection systems should consider the oxygen concentration and ROS reaction. (C) 2008 Elsevier Ltd. All rights reserved.
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