Effects of 4 Different Alloplastic Materials on Bone Regeneration in Rabbit Calvarial Defects

Abstract

The purpose of this study was to compare bone regeneration in 8-mm defects in 8 New Zealand White rabbit calvaria using 4 different alloplastic bone substitutes. Four 8-mm calvarial defects were made in the parietal bone of each animal. The defects were filled with Bongros-HA (TM) (Bioalpha, Seongnam, Korea), micro macroporous biphasic calcium phosphate(MBCP (TM), Biomatlante, France), Osteon (TM)(Dentium Co, Seoul, Korea) and Cerasorb (R)(Curasan, Kleinsthei, Germany). Two animals died after surgery. Two rabbits were sacrificed after 4 weeks, and the other 4 were sacrificed after 8 weeks. Data analysis included the qualitative assessment of the calvarial specimens. Histomorphometric analysis was performed to quantify the amount of new bone within the defects. It was found that Osteon (TM)-treated defects had significantly more new bone after 8 weeks thanall other groups. Osteon (TM) was an effective alloplastic bone substitute which showed reliable osseous healing of critical size defects in the rabbit calvarium. From the results of this study, it is suggested that TCP-coated HA may induce a better bone regeneration ability than either HA or TCP or both.