O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Kihong | - |
dc.contributor.author | Chang, Hyo-Ihl | - |
dc.date.accessioned | 2021-09-08T20:00:01Z | - |
dc.date.available | 2021-09-08T20:00:01Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-02-04 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120593 | - |
dc.description.abstract | Sp1 is a ubiquitous transcription factor that is modified by multiple O-linked N-acetylglucosamines (O-GlcNAc). Previously, O-GlcNAcylation of a specific site of Sp1 was shown to inhibit Sp1 transcriptional activity. Yet, how O-GlcNAc on other modi. cation sites affects Sp1 function and how O-GlcNAcylation of Sp1 affects the transcriptional regulation of a target gene remains unknown. Here we show that O-GlcNAc within the second serine/threonine-rich region of Sp1 interrupts a known interaction between Sp1 and Oct1, and inhibits the cooperative activation of the U2 snRNA gene by Sp1 and Oct1. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | TRANSCRIPTION FACTORS SP1 | - |
dc.subject | N-ACETYLGLUCOSAMINE | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | GLYCOSYLATION | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEASOME | - |
dc.subject | BINDING | - |
dc.subject | CELLS | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | SUSCEPTIBILITY | - |
dc.title | O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Kihong | - |
dc.contributor.affiliatedAuthor | Chang, Hyo-Ihl | - |
dc.identifier.doi | 10.1016/j.febslet.2008.12.007 | - |
dc.identifier.scopusid | 2-s2.0-58649098191 | - |
dc.identifier.wosid | 000263603600003 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.583, no.3, pp.512 - 520 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 583 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 512 | - |
dc.citation.endPage | 520 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS SP1 | - |
dc.subject.keywordPlus | N-ACETYLGLUCOSAMINE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | GLYCOSYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEASOME | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordAuthor | O-GlcNAc | - |
dc.subject.keywordAuthor | Oct1 | - |
dc.subject.keywordAuthor | Sp1 | - |
dc.subject.keywordAuthor | U2 snRNA | - |
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