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O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1

Authors
Lim, KihongChang, Hyo-Ihl
Issue Date
4-2월-2009
Publisher
WILEY
Keywords
O-GlcNAc; Oct1; Sp1; U2 snRNA
Citation
FEBS LETTERS, v.583, no.3, pp.512 - 520
Indexed
SCIE
SCOPUS
Journal Title
FEBS LETTERS
Volume
583
Number
3
Start Page
512
End Page
520
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120593
DOI
10.1016/j.febslet.2008.12.007
ISSN
0014-5793
Abstract
Sp1 is a ubiquitous transcription factor that is modified by multiple O-linked N-acetylglucosamines (O-GlcNAc). Previously, O-GlcNAcylation of a specific site of Sp1 was shown to inhibit Sp1 transcriptional activity. Yet, how O-GlcNAc on other modi. cation sites affects Sp1 function and how O-GlcNAcylation of Sp1 affects the transcriptional regulation of a target gene remains unknown. Here we show that O-GlcNAc within the second serine/threonine-rich region of Sp1 interrupts a known interaction between Sp1 and Oct1, and inhibits the cooperative activation of the U2 snRNA gene by Sp1 and Oct1.
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