Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jung Won | - |
dc.contributor.author | Min, Hyun Jung | - |
dc.contributor.author | Sohn, Jung Ho | - |
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | Hong, Jeong Ho | - |
dc.contributor.author | Sigrist, Kirsten S. | - |
dc.contributor.author | Glimcher, Laurie H. | - |
dc.contributor.author | Hwang, Eun Sook | - |
dc.date.accessioned | 2021-09-08T20:04:19Z | - |
dc.date.available | 2021-09-08T20:04:19Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120616 | - |
dc.description.abstract | Background: A Till-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T-H cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce T(H)2 cytokines and have spontaneous airway inflammation. Objectives: We tested whether T-bet overexpression could protect against the development or progression of asthma. Methods: We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model. Results: Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T(H)2 cytokine production by peripheral T cells. Even when T-bet expression was induced (luring later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T(H)2 cytokine production. Conclusions: Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma. (J Allergy Clin Immunol 2009;123:479-85.) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.subject | IFN-GAMMA | - |
dc.subject | LINEAGE COMMITMENT | - |
dc.subject | AIRWAY INFLAMMATION | - |
dc.subject | TH1 CELLS | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | BET EXPRESSION | - |
dc.subject | GENE | - |
dc.subject | CD4 | - |
dc.subject | HYPERRESPONSIVENESS | - |
dc.subject | LYMPHOCYTES | - |
dc.title | Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Jeong Ho | - |
dc.identifier.doi | 10.1016/j.jaci.2008.10.035 | - |
dc.identifier.scopusid | 2-s2.0-59449090710 | - |
dc.identifier.wosid | 000263495000029 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.123, no.2, pp.479 - 485 | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.volume | 123 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 479 | - |
dc.citation.endPage | 485 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | LINEAGE COMMITMENT | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | TH1 CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | BET EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CD4 | - |
dc.subject.keywordPlus | HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordAuthor | T-bet | - |
dc.subject.keywordAuthor | T cell | - |
dc.subject.keywordAuthor | transgenic mice | - |
dc.subject.keywordAuthor | OVA | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | airway hyperresponsiveness | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.