Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma
- Authors
- Park, Jung Won; Min, Hyun Jung; Sohn, Jung Ho; Kim, Joo Young; Hong, Jeong Ho; Sigrist, Kirsten S.; Glimcher, Laurie H.; Hwang, Eun Sook
- Issue Date
- 2월-2009
- Publisher
- MOSBY-ELSEVIER
- Keywords
- T-bet; T cell; transgenic mice; OVA; asthma; airway hyperresponsiveness
- Citation
- JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.123, no.2, pp.479 - 485
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Volume
- 123
- Number
- 2
- Start Page
- 479
- End Page
- 485
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120616
- DOI
- 10.1016/j.jaci.2008.10.035
- ISSN
- 0091-6749
- Abstract
- Background: A Till-specific transcription factor, T-box-containing protein expressed in T cells (T-bet), controls the production of both T(H)1 and T(H)2 cytokines in T-H cell differentiation by means of distinct mechanisms. T-bet-deficient mice overproduce T(H)2 cytokines and have spontaneous airway inflammation. Objectives: We tested whether T-bet overexpression could protect against the development or progression of asthma. Methods: We generated a T cell-specific and inducible line of T-bet-transgenic mice on a T-bet-deficient genetic background and used it to study the function of T-bet in an ovalbumin (OVA)-induced asthma model. Results: Induction of T-bet in a T cell-specific manner in an OVA model of asthma concomitant with OVA injection prevented airway hyperresponsiveness, eosinophilic and lymphocytic inflammation, and IL-5 and IL-13 production in bronchoalveolar lavage fluid and also reduced serum IgE and T(H)2 cytokine production by peripheral T cells. Even when T-bet expression was induced (luring later stages of asthma progression, T-bet overexpression still attenuated airway hyperresponsiveness and goblet cell hyperplasia, as well as T(H)2 cytokine production. Conclusions: Our results suggest that T-bet expression in T cells can prevent the initiation of airway inflammation and progression of chronic inflammation and might be extrapolated to human asthma. (J Allergy Clin Immunol 2009;123:479-85.)
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.