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Impact of Obstructive Sleep Apnea on the Atrial Electromechanical Activation Time

Authors
Lim, Hong EuyKim, Yong HyunKim, Seong HwanKim, Eung JuPak, Hui-NamKim, Young-HoonBaik, InkyungShin, Choi
Issue Date
Feb-2009
Publisher
JAPANESE CIRCULATION SOC
Keywords
Apnea-hypopnea index; Atrial remodeling; Obstructive sleep apnea; Tissue Doppler imaging
Citation
CIRCULATION JOURNAL, v.73, no.2, pp 249 - 255
Pages
7
Indexed
SCIE
SCOPUS
Journal Title
CIRCULATION JOURNAL
Volume
73
Number
2
Start Page
249
End Page
255
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120697
DOI
10.1253/circj.CJ-08-0813
ISSN
1346-9843
1347-4820
Abstract
Background Obstructive sleep apnea (OSA) is closely associated with atrial fibrillation, which is provoked by electrical and structural remodeling. However, the association between OSA and atrial remodeling has not been fully elucidated. Methods and Results Atrial electromechanical activation time (EMAT) was investigated using tissue Doppler imaging (TDI) in men with severe OSA (n=24) and control subjects (n=24). The EMAT was determined as the time interval from the initiation of P-wave deflection until the peak of local lateral left atrial (LA) TDI signal. The early diastolic velocity of the mitral annulus (Ea) and the EMAT were significantly lower and longer in OSA cases than in controls (Ea: 6.1 +/- 0.9 cm/s vs 7.3 +/- 1.5 cm/s, P=0.001; EMAT: 129.7 +/- 11.5 ms vs 118.5 +/- 12.3 ms, P=0.002). Among OSA cases, the apnea-hypopnea index (AHI) was significantly correlated with EMAT (r=0.660, P<0.001), Ea (r=-0.609, P=0.002), LA dimension (r=0.486, P=0.016), and early diastolic velocity of mitral flow (E)/Ea ratio (r=0.418, P=0.042). In multivariate stepwise linear regression analysis, EMAT was independently associated with AHI (P=0.025) and Ea (P=0.028) in OSA cases. Conclusion EMAT measured by TDI could be a useful parameter for identifying atrial remodeling in patients with severe OSA. (Circ J 2009,73:249-255)
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