Docetaxel and epirubicin salvage regimen in relapsed anthracycline-sensitive metastatic breast cancer patients after anthracycline-containing adjuvant therapy
- Authors
- Seo, Jae Hong; Sung, Hwa Jung; Park, Kyong Hwa; Choi, In Keun; Oh, Sang Cheul; Shin, Sang Won; Kim, Yeul Hong; Kim, Jun Suk; Kim, Ae-Ree; Lee, Jae-Bok; Koo, Bum Hwan
- Issue Date
- 2월-2009
- Publisher
- SPRINGER
- Keywords
- Epirubicin; Docetaxel; Anthracycline; Sensitive; Metastatic breast cancer
- Citation
- INVESTIGATIONAL NEW DRUGS, v.27, no.1, pp.67 - 73
- Indexed
- SCIE
SCOPUS
- Journal Title
- INVESTIGATIONAL NEW DRUGS
- Volume
- 27
- Number
- 1
- Start Page
- 67
- End Page
- 73
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120704
- DOI
- 10.1007/s10637-008-9151-2
- ISSN
- 0167-6997
- Abstract
- Our aim in this paper is to verify the efficacy and safety of a epirubicin and docetaxel salvage regimen for anthracycline sensitive metastatic breast cancer patients who have relapsed after anthracycline-containing adjuvant therapy. Thirty-two metastatic breast cancer patients were treated with epirubicin and docetaxel every 21 days. Of the 31 evaluable patients, there were 13/31 (41.9%) partial responses and no complete responses. Median time to progression was 12 months (95% CI, 4-60 months) and median survival duration was 41 months (95% CI, 1.2-80.8 months). According to the Cox model, ECOG performance and response group were statistically significant variables, and visceral metastasis was a borderline significant variable with regards to overall survival. Although this salvage regimen showed a high rate of hematologic toxicities, it was a relatively active regimen with manageable toxicities and no cardiac dysfunction. We propose that this salvage regimen could be carefully used in anthracycline sensitive metastatic breast cancer patients who have relapsed after anthracycline-containing adjuvant therapy.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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