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Improvement of Diabetic Complication by Hydrangea Dulcis Folium in Streptozotocin-Induced Diabetic Rats

Authors
Kim, Hye KyungKim, Mi JeongLyu, Eun SoonShin, Dong-Hoon
Issue Date
1월-2009
Publisher
PHARMACEUTICAL SOC JAPAN
Keywords
streptozotocin-diabetes; Hydrangea Dulcis Folium; insulin; glucose tolerance; lipid profile; antioxidant enzyme
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.32, no.1, pp.153 - 156
Indexed
SCIE
SCOPUS
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume
32
Number
1
Start Page
153
End Page
156
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120795
DOI
10.1248/bpb.32.153
ISSN
0918-6158
Abstract
The improvement of diabetic complications such as lipid lowering and anti-oxidative potential of Hydrangea Dulcis Folium (HDF) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into 3 groups after induction of streptozotocin (STZ)-diabetes: normal control; diabetic control; diabetic-HDF supplement (hot water extract 40g/kg diet); and fed experimental diets for 3weeks. Serum glucose and insulin concentrations, serum lipid profile, intraperitoneal glucose tolerance test, and liver cytosolic antioxidant enzyme levels were measured. The HDF supplement significantly decreased serum glucose concentration, increased insulin level, and improved glucose homeostasis in diabetic control rats. The total cholesterol and triglyceride concentrations in the serum and liver were markedly reduced by HDF treatment in STZ-diabetic rats. Moreover, low density lipoprotein (LDL)-, VLDL-, and high density lipoprotein (HDL)-cholesterol levels were ameliorated in HDF supplemented diabetic rats. Decreased fecal excretions of cholesterol, triglyceride, and bile acid in diabetic rats were significantly increased by HDF consumption. HDF supplement reversed the effects of the oxidative stress system of liver in diabetic rats. Lipid peroxidation of diabetic rats, assessed by thiobarbituric acid reactive substance (TBARS), as well as superoxide dismutase (SOD) activities were significantly increased, and glutathione contents were decreased in diabetic rats. HDF supplement reverted these parameters to near normal value. Our data suggest that HDF supplement could be used to improve the glucose and lipid metabolism as well as to reduce the imbalance between the generation of reactive oxygen species (ROS) and the scavenging enzyme activity in preventing diabetic complications.
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