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Bioassay-guided isolation of antiplasmodial anacardic acids derivatives from the whole plants of Viola websteri Hemsl
- Authors
- Lee, Sung Jae; Park, Won-Hwan; Moon, Hyung-In
- Issue Date
- Jan-2009
- Publisher
- SPRINGER
- Citation
- PARASITOLOGY RESEARCH, v.104, no.2, pp.463 - 466
- Indexed
- SCIE
SCOPUS
- Journal Title
- PARASITOLOGY RESEARCH
- Volume
- 104
- Number
- 2
- Start Page
- 463
- End Page
- 466
- ISSN
- 0932-0113
- Abstract
- The petroleum ether extract of Viola websteri Hemsl. (Violaceae) was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. The main antiplasmodial principles, 6-(8'Z-pentadecenyl)-salicylic acid (1) and 6-(8'Z, 11'Z, 14'Z-heptadecatrienyl)-salicylic acid (2), have been isolated from V. websteri for the first time. This is the first report on the antiplasmodial activity of the compounds from V. websteri.
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