Persistent dysarthria after cefazolin-induced status epilepticus
- Authors
- Lee, Yuna; Pyun, Sung-Bom; Park, Eun Kyung; Youn, Sung Won
- Issue Date
- 2009
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Dysarthria; seizure; rehabilitation; drug use; cognition
- Citation
- BRAIN INJURY, v.23, no.10, pp 846 - 851
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRAIN INJURY
- Volume
- 23
- Number
- 10
- Start Page
- 846
- End Page
- 851
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120902
- DOI
- 10.1080/02699050903196704
- ISSN
- 0269-9052
1362-301X
- Abstract
- Background: Cefazolin is a well-known antibiotic associated with seizures. However, intrathecal cefazolin-induced status epilepticus (SE) is very rare and resultant persistent dysarthria has not been previously reported. Case report: A 66-year-old woman underwent epidural adhesiolysis due to lumbar spinal stenosis and 500 mg of cefazolin was infused through the thecal puncture site during the procedure. SE developed abruptly 40 minutes later and it persisted for 3 days. Severe dysarthria, dysphagia and cognitive dysfunction developed after the cessation of SE. Although the patient's other symptoms showed much improvement after rehabilitation, the dysarthria did not improve after intense speech therapy for 8 months. The brain MRI showed no abnormal findings, but the 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) of the brain demonstrated hypometabolic areas in the bilateral inferior frontal gyrus and the primary motor cortex, representing the oromotor area. Conclusion: Although the exact mechanism underlying the dysarthria is unknown, the dysfunction of the inferior frontal network for speech production revealed by the brain FDG-PET, including the motor speech area (Broca's area), left insula and bilateral primary and premotor cortex representing the oromotor area, might have been responsible for the persistent dysarthria in this patient.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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