백서에서 바질 에센셜 오일의 항통각 효과Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice
- Other Titles
- Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice
- Authors
- 민선식; 한승호; 이재용; 김찬; 설근희; 임재형; 김형태; 이규창; 김혜영; 이명종
- Issue Date
- 2009
- Publisher
- 대한통증학회
- Keywords
- antinociception; essential oil of ocimum basilicum; formalin test; plantar test
- Citation
- The Korean Journal of Pain, v.22, no.3, pp.206 - 209
- Indexed
- KCI
- Journal Title
- The Korean Journal of Pain
- Volume
- 22
- Number
- 3
- Start Page
- 206
- End Page
- 209
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121103
- ISSN
- 2005-9159
- Abstract
- Background: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB.
Methods: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 ㎎/㎏, 100 ㎎/㎏, 150 ㎎/㎏) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 ㎎/㎏, 100 ㎎/㎏) was administered and the withdrawal latency was measured using the Hargreaves method.
Results: In the formalin test, EOOB (50 ㎎/㎏, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined.
Conclusions: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
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