Atorvastatin과 Calcium Channel Blocker 사용 환자에서의 콜키신 유발 급성 근육병증: 증례보고의 사례A Case of Colchicine Induced Acute Myopathy in Atorvastatin and Calcium Channel Blocker User
- Other Titles
- A Case of Colchicine Induced Acute Myopathy in Atorvastatin and Calcium Channel Blocker User
- Authors
- 권유하; 강효정; 이지훈; 김동휘; 황미령
- Issue Date
- 2009
- Publisher
- 대한근전도전기진단의학회
- Keywords
- Colchinice; Atorvastatin; Myopathy; Neuropathy
- Citation
- 대한근전도 전기진단의학회지, v.11, no.2, pp.169 - 173
- Journal Title
- 대한근전도 전기진단의학회지
- Volume
- 11
- Number
- 2
- Start Page
- 169
- End Page
- 173
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121161
- DOI
- 10.18214/jkaem.2009.11.2.169
- ISSN
- 2733-6581
- Abstract
- Myopathy is a rare side effect of chronic colchicine therapy, most often occurring in patients with chronic
renal failure. Colchicine and 3-hydroxy-3-methy-glutaryl coenzyme A (HMG-CoA) reductase inhibitors
are well known to cause myopathy. We report the case of a patient with chronic renal failure who had
been taking atorvastatin and calcium channel blocker and developed acute weakness 7 days after the initiation
of colchicines therapy for gouty attack. A 58-year-old woman on colchicine 0.6 mg twice a day for
7 days, developed subacute onset of painless proximal muscle weakness with elevation of creatine phosphokinase
(CPK) level. Nerve conduction studies revealed a mild axonal and demyelinating neuropathy
affecting the arms and legs and needle electromyography showed non-specific findings indicating myopathy.
After withdrawal of colchicine, serum CPK levels returned to normal and her weakness resolved over
a period. In our patient, neurological toxicity was induced and accerlated by coadministration of
colchicines with atorvastatin and calcium channel blocker in the presence of impaired renal function.
Colchicine is to be used with caution in patients with impaired renal function especially in those who are
concomitantly administering other drugs that may further inhibit colchicine clearance.
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