알츠하이머병, 경도인지장애 및 정상 대조군의 뇌량 면적과 뇌 용적의 비교

Abstract

Purpose: To compare the corpus callosum (CC) area and brain volume among individuals with Alzheimer’s disease (AD), mild cognitive impairment (MCI) and healthy controls (HC). Materials and Methods: To evaluate the relationship of CC area and brain volume in 111 subjects (M:F = 48:63; mean age, 56.9 years) without memory disturbance and 28 subjects (11:17; 66.7years) with memory disturbance. The 11 AD (3:8; 75.7 years), 17 MCI (8:9; 60.9 years) and 28 selected HC (11:17; 66.4 years) patients were investigated for comparison of their CC area and brain volume. Results: A good positive linear correlation was found between CC area and brain volume in subjects without and with memory disturbance (r = 0.64 and 0.66, respectively, p < 0.01). The CC area and brain volume in AD patients (498.7 ± 72 mm², 715.4 ± 107 cm³) were significantly smaller than in MCI patients (595.9 ± 108, 844.1 ± 85) and the HCs (563.2 ± 75, 818.9 ± 109) (p < 0.05). The CC area and brain volume were not significantly different between MCI patients and the HCs. Conclusion: The CC area was significantly correlated with brain volume. Both CC area and brain volume were significantly smaller in the AD patients.