알츠하이머병, 경도인지장애 및 정상 대조군의 뇌량 면적과 뇌 용적의 비교The Corpus Callosum Area and Brain Volume in Alzheimer’s Disease, Mild Cognitive Impairment and Healthy Controls
- Other Titles
- The Corpus Callosum Area and Brain Volume in Alzheimer’s Disease, Mild Cognitive Impairment and Healthy Controls
- Authors
- 최희석; 서형석; 김광기; 윤엽
- Issue Date
- 2009
- Publisher
- 대한영상의학회
- Keywords
- Alzheimer’s disease; Cognition disorders; Corpus callosum; Magnetic resonance (MR); Brain
- Citation
- 대한영상의학회지, v.61, no.1, pp.1 - 8
- Indexed
- KCI
- Journal Title
- 대한영상의학회지
- Volume
- 61
- Number
- 1
- Start Page
- 1
- End Page
- 8
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121170
- ISSN
- 1738-2637
- Abstract
- Purpose: To compare the corpus callosum (CC) area and brain volume among individuals with Alzheimer’s disease (AD), mild cognitive impairment (MCI) and healthy controls (HC).
Materials and Methods: To evaluate the relationship of CC area and brain volume in 111 subjects (M:F = 48:63; mean age, 56.9 years) without memory disturbance and 28 subjects (11:17; 66.7years) with memory disturbance. The 11 AD (3:8; 75.7 years), 17 MCI (8:9; 60.9 years) and 28 selected HC (11:17; 66.4 years) patients were investigated for comparison of their CC area and brain volume.
Results: A good positive linear correlation was found between CC area and brain volume in subjects without and with memory disturbance (r = 0.64 and 0.66, respectively, p < 0.01). The CC area and brain volume in AD patients (498.7 ± 72 mm², 715.4 ± 107 cm³) were significantly smaller than in MCI patients (595.9 ± 108, 844.1 ± 85) and the HCs (563.2 ± 75, 818.9 ± 109) (p < 0.05). The CC area and brain volume were not significantly different between MCI patients and the HCs.
Conclusion: The CC area was significantly correlated with brain volume. Both CC area and brain volume were significantly smaller in the AD patients.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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