요 트립신 억제제가 패혈증 환자의 예후에 미치는 영향The Effects of Urinary Trypsin Inhibitor on the Outcomes of Severe Sepsis and Septic Shock Patients
- Other Titles
- The Effects of Urinary Trypsin Inhibitor on the Outcomes of Severe Sepsis and Septic Shock Patients
- Authors
- 문성우; 홍윤식; 윤영훈; 박대원; 장익진; 임성익; 이성우
- Issue Date
- 2009
- Publisher
- 대한응급의학회
- Keywords
- Septic shock; Severe sepsis; Urinary trypsin
inhibitor
- Citation
- 대한응급의학회지, v.20, no.1, pp.80 - 85
- Indexed
- KCI
- Journal Title
- 대한응급의학회지
- Volume
- 20
- Number
- 1
- Start Page
- 80
- End Page
- 85
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121183
- ISSN
- 1226-4334
- Abstract
- Purpose: We purposed to determine the effects of urinary
typsin inhibitor (ulinastatin) on the outcomes of severe sepsis
and septic shock patients.
Methods: This is a prospective case control study of
severe sepsis and septic shock patients who visited emergency
department of university hospital from January 2005
to June 2008. For study group, 100,000 U of ulinastatin was
initially infused and then additional infusions of ulinastatin
were determined by the mean arterial pressure. We compared
the predicted mortality and the actual in-hospital mortality
between the ulinastatin group and the control group.
We also compared the improvement of the SOFA score
according to time between the groups.
Results: There were 43 patients in the ulinastatin group
and 126 patients in the control group. The predicted mortality
and the actual mortality of the ulinastatin group were
31.2% and 18.6%, respectively. The predicted and actual
mortalities of the control group were 33.1% and 27.0%,
respectively. The improvement of the SOFA score for the
ulinastatin group was 6.8±3.9 and 5.0±4.5 at 0 and 24
hours (p<0.001), 6.5±3.7 and 3.9±4.3 at 0 and 48 hours
(p<0.001) and, 6.3±3.6 and 3.0±4.1 at 0 and 72 hours
(p<0.001). For the control group, the change of the SOFA
score was 4.9±2.9 and 5.8±4.1 at 0 and 24 hours
(p=0.003), 5.0±2.8 and 5.1±4.2 at 0 and 48 hours
(p=0.760) and, 4.8±2.7 and 4.3±4.1 at 0 and 72 hours
(p=0.105).
Conclusion: The ulinastatin group showed significantly
lower mortality than the predicted mortality and the ulinastatin
group’s SOFA score was improved in the early hospital
days.
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