Effects of fruits and stems of opuntia ficus-indica on blood glucose and lipid metabolism in streptozotocin-induced diabetic rats
- Authors
- Yoon, J.A.; Son, Y.-S.
- Issue Date
- 2009
- Keywords
- Blood glucose; Cholesterol; Insulin; Opuntia ficus-indica; Streptozotocin
- Citation
- Journal of the Korean Society of Food Science and Nutrition, v.38, no.2, pp.146 - 153
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of the Korean Society of Food Science and Nutrition
- Volume
- 38
- Number
- 2
- Start Page
- 146
- End Page
- 153
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121909
- DOI
- 10.3746/jkfn.2009.38.2.146
- ISSN
- 1226-3311
- Abstract
- This study was conducted to examine the effects of fruits and stems of Opuntia ficus-indica var. saboten Makino on water intake, feed intake, body weight, blood glucose level and glucose tolerance in streptozotocin (STZ)-induced diabetic rats. Forty Sprague-Dawley male rats were divided into non-diabetic control (NC), diabetic control (DC), 8% Opuntia fruit (DOF), 5% Opuntia stem (DO-5) and 10% Opuntia stem (DO-10) groups. Fruits and stems of Opuntia ficus-indica were freeze-dried and ground before use in the experiment. Animals were fed experimental diet for 3 weeks. DOF, DO-5 and DO-10 groups showed lower water and feed intake as well as less body weight loss than DC group. The fasting blood glucose levels were 100 mg/dL for NC and 379 mg/dL for DC. Fasting glucose level of DOF was a significantly low level of 28% (p<0.05), whereas DO-5 and DO-10 had a decrease of 5% and 9% compared to DC. As for the glucose tolerance test, the highest blood glucose levels for NC and DC-10 group were observed at 30 minutes after glucose injection while those of DOF and DO-5 groups were after 60 minutes. DOF and DO-5 plasma insulin level improved. Plasma total cholesterol, triglyceride, non-esterified fatty acid (NEFA) and LDL-cholesterol concentrations were also lower in DOF, DO-5 and DO-10 groups, although HDL-cholesterol level was only slightly affected by experimental diets compared to DC. These results suggest that the feeding of Opuntia ficus-indica fruits and stems improved blood glucose and lipid metabolism in STZ-induced diabetic rats.
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Collections - College of Life Sciences and Biotechnology > Division of Biotechnology > 1. Journal Articles
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